CONTRIBUTION OF VESTIBULAR COMMISSURAL PATHWAYS TO SPATIAL ORIENTATION OF THE ANGULAR VESTIBULOOCULAR REFLEX

During nystagmus induced by the angular vestibuloocular reflex (aVOR), the axis of eye velocity tends to align with the direction of gravito inertial acceleration (GIA), a process we term ''spatial orientation o f the aVOR.'' We studied spatial orientation of the aVOR in rhesus and cynomolgus monkeys before and after midline section of the rostral me dulla abolished all oculomotor functions related to velocity storage, leaving the direct optokinetic and vestibular pathways intact. Optokin etic afternystagmus and the bias component of off-vertical-axis rotati on were lost, and the aVOR time constant was reduced to a value commen surate with the time constants of primary semicircular canal afferents . Spatial orientation of the aVOR, induced either during optokinetic o r vestibular stimulation, was also lost. Vertical and roll aVOR time c onstants could no longer be lengthened in side-down or supine/prone po sitions, and static and dynamic tilts of the GIA no longer produced cr oss-coupling from the yaw to pitch and yaw to roll axes. Consequently, the induced nystagmus remained entirely in head coordinates after the lesion, regardless of the direction of the resultant GIA vector. Gain s of the aVOR and of optokinetic nystagmus to steps of velocity were u naffected or slightly increased. These results are consistent with a m odel in which the direct aVOR pathways are organized in semicircular c anal coordinates and spatial orientation is restricted to the indirect (velocity storage) pathways.