PREPARATION AND ANTICOAGULANT SURFACE-PROPERTIES OF GLUCOSIDE-BEARINGOR SULFATED-GLUCOSIDE-BEARING POLYMER-GRAFTED POLY(ETHYLENE) FILMS

Poly(GEMA) or poly(GEMA)-sulfate grafted surfaces were prepared for th e purpose of developing biomaterials with anticoagulant surfaces. Thei r functionalities were investigated as anticoagulant activity, protein s and cells adhesion activity, and complement activation activity. The se results revealed that the adhesion of blood cells onto a GEMA-sulfa te grafted surface was due to protein adsorption and that complement a ctivation onto a GEMA-sulfate grafted surface was larger than that on a GEMA grafted surface. A GEMA-sulfate grafted surface, however, exhib ited good anticoagulant activity. These functions seemed to be due to the specific functionality of the SO3 groups in a GEMA-sulfate.