INTERFERENCE WITH VANCOMYCIN FLUORESCENCE POLARIZATION IMMUNOASSAY INA NONURAEMIC PATIENT

Commercially available immunoassays for vancomycin have been reported to overestimate serum vancomycin concentrations by varying degrees in patients with renal impairment, particularly those on peritoneal dialy sis, by interference with crystalline degradation product-1 (CDP-1). T o date this interference has not been reported in any other patient po pulation. This report describes vancomycin fluorescence polarisation i mmunoassay (FPIA) interference in a patient with only mildly impaired renal function. At this time it is not possible to confirm that the in terference was caused by CDP-1.