ORAL ALUMINUM ADMINISTRATION AND OXIDATIVE INJURY

Citation
R. Katyal et al., ORAL ALUMINUM ADMINISTRATION AND OXIDATIVE INJURY, Biological trace element research, 57(2), 1997, pp. 125-130
Citations number
17
Categorie Soggetti
Biology
ISSN journal
01634984
Volume
57
Issue
2
Year of publication
1997
Pages
125 - 130
Database
ISI
SICI code
0163-4984(1997)57:2<125:OAAAOI>2.0.ZU;2-S
Abstract
For a long time, aluminium (Al) has been considered an indifferent ele ment from a toxicological point of view. In recent years, however, Al has been implicated in the pathogenesis of several clinical disorders, such as dialysis dementia, the fulminant neurological disorder that c an develop in patients on renal dialysis. In the present study, the ef fect of chronic oral administration of Al on certain biochemical param eters of brain homogenate has been investigated. The feeding of test d iet for 6 wk resulted in a decrease of thiols, glutathione reductase ( GR), and adenosine Triphosphatase (ATPase). A nonsignificant decrease in peroxidation and glutathione-S-transferase (GST) was also detected in the Al-treated rats. From this study, it can be concluded that oxid ative stress is produced by the metal.