A. Matsuda et al., INFLUENCE OF SELENIUM DEFICIENCY ON THE ACUTE CARDIOTOXICITY OF ADRIAMYCIN IN RATS, Biological trace element research, 57(2), 1997, pp. 157-167
The influence of selenium (Se) deficiency on the acute cardiotoxicity
induced by the anticancer drug adriamycin (ADR) has been studied in ra
ts by electrocardiography. Two categories were formed by feeding group
s of rats a Se-supplemented and a Se-deficient diet. The supplemented
animals were taken as normals. The two categories were treated with iv
injections of saline solution containing ADR at doses of 0, 7.5, and
15 mg/kg body wt. The cardiac Se concentration and glutathione peroxid
ase (GSH-Px) activity in the Se-deficient groups were <2% lower than i
n the normals. The normal groups showed significant widening of the Sa
T and QaT durations when given 15 mg/kg ADR. The Se-deficient groups e
xhibited a dose-dependent widening of the SaT and QaT duration at 7.5
and 15 mg/kg and narrowing of the PO duration at 15 mg/kg ADR. No hear
t rate or QRS duration changes were detected in both categories. Our r
esults suggest that an imbalance of the antioxidant system is associat
ed with Se deficiency and that Se plays a role in preventing the cardi
ac functional disorder attributable to oxygen free radical formation i
nduced by ADR.