(-)-(R)-5,5-DIMETHYLMORPHOLINYL-2-ACETIC ACID ETHYL-ESTER HYDROCHLORIDE, C10H20NO3-(.CL)

Authors
FRYDENVANG K ENNA SJ KROGSGAARDLARSEN P
Citation
K. Frydenvang et al., (-)-(R)-5,5-DIMETHYLMORPHOLINYL-2-ACETIC ACID ETHYL-ESTER HYDROCHLORIDE, C10H20NO3-(.CL), Acta crystallographica. Section C, Crystal structure communications, 53, 1997, pp. 1088-1091
Citations number
18
Categorie Soggetti
Crystallography
Journal title
Acta crystallographica. Section C, Crystal structure communications → ACNP
ISSN journal
01082701
Volume
53
Year of publication
1997
Part
8
Pages
1088 - 1091
Database
ISI
SICI code
0108-2701(1997)53:<1088:(AEH>2.0.ZU;2-2
Abstract
One of the enantiomers of 5,5-dimethylmorpholinyl-2-acetic acid is obs erved to be a GABA(B) receptor antagonist. The absolute configuration of the inactive enantiomer is found to be the R configuration. The mor pholine ring adopts a chair conformation with the acetic acid moiety i n an equatorial position. In the crystal packing, hydrogen bonds are o bserved between the ammonium group and the chloride ions.