REGULATION OF SIGNAL-TRANSDUCTION THROUGH THE T-CELL ANTIGEN RECEPTOR

Considerable work from numerous laboratories has provided important in sights into the biology of T cell activation. Much has been learned ab out the most proximal signaling events that occur after engagement of the T cell antigen receptor and other cell-surface receptors on T lymp hocytes. However, our understanding of how various signaling pathways are integrated, resulting in cellular proliferation and cytokine produ ction or conversely leading to programmed cell death, is far from comp lete. We summarize what is now known about some of the proximal signal s that result from engagement of the T cell antigen receptor and how s ome of these signals are linked to cellular responses.