Based on previous reports of relaxation-induced panic attacks in panic
disorder patients, quantitative electroencephalographic (EEG) profile
s and subjective anxiety ratings were assessed in panic disorder patie
nts and normal controls listening to neutral and relaxation audiotapes
. Regardless of tape condition, patients exhibited a greater frequency
and severity of panic-related symptoms. Relaxation failed to alter pa
nic-related symptom ratings or anxiety ratings in patients and control
s. Theta and alpha increments were observed during relaxation, bur onl
y in normal controls. High frequency beta activity was less evident in
patients, regardless of tape condition. Results are discussed in rela
tion to arousal and treatment issues in panic disorder. (C) 1997 Elsev
ier Science Ltd.