L. Birksorensen et al., SEDIMENTATION OF FORMED ELEMENTS IN DISTALLY ISCHEMIC FLAPS, Scandinavian journal of plastic and reconstructive surgery and hand surgery, 31(3), 1997, pp. 203-211
Our aim was to find out whether thrombosis has a key role in distally
ischaemic flaps and whether heparin improves flap survival in distally
ischaemic myocutaneous and pure skin flaps in pigs. In experiment 1 w
e measured the concentration of coagulation factors in the venous effl
uent from both viable flaps and distally ischaemic flaps. In experimen
t 2 radioactively labelled blood components (red cells, platelets and
fibrinogen) were injected intravenously and the distribution of each t
racer was measured. In experiment 3 either heparin or saline was given
as a local, continuous direct intra-arterial infusion. Fluorescein wa
s used in all experiments to estimate the eventual flap survival. Our
results indicate that thrombosis is not an important factor in distal
ischaemia, and that heparin did not improve survival. Instead, there s
eems to be selective pooling of formed elements in the ischaemic porti
on of the flap.