THE SKIN AND THE GUT IN PSORIASIS - THE NUMBER OF MAST-CELLS AND CD3-CELLS IN THE DUODENUM( LYMPHOCYTES IS INCREASED IN NONINVOLVED SKIN AND CORRELATED TO THE NUMBER OF INTRAEPITHELIAL LYMPHOCYTES AND MAST)

Citation
G. Michaelsson et al., THE SKIN AND THE GUT IN PSORIASIS - THE NUMBER OF MAST-CELLS AND CD3-CELLS IN THE DUODENUM( LYMPHOCYTES IS INCREASED IN NONINVOLVED SKIN AND CORRELATED TO THE NUMBER OF INTRAEPITHELIAL LYMPHOCYTES AND MAST), Acta dermato-venereologica, 77(5), 1997, pp. 343-346
Citations number
18
Categorie Soggetti
Dermatology & Venereal Diseases
Journal title
ISSN journal
00015555
Volume
77
Issue
5
Year of publication
1997
Pages
343 - 346
Database
ISI
SICI code
0001-5555(1997)77:5<343:TSATGI>2.0.ZU;2-3
Abstract
The aim of this work was to study tryptase + mast cells and CD3 + T ly mphocytes in non-involved skin in psoriasis and their possible relatio n to mast cells and lymphocytes in the duodenal mucosa, Skin biopsy sp ecimens were obtained from 43 patients with psoriasis of variable seve rity and from 10 healthy subjects, Compared with the reference subject s, the number of mast cells in non-involved skin was clearly increased , most markedly in the papillary dermis, The increase was present both in mild, moderate and severe psoriasis. CD3+ lymphocytes were increas ed in noninvolved skin in moderate and severe psoriasis. Patients with an increased number of duodenal intraepithelial lymphocytes had signi ficantly more mast cells in non-involved skin than those without such an increase, and there was a significant correlation between the numbe r of mast cells in noninvolved skin and score for intraepithelial lymp hocytes, However, when the 14 patients with increased intraepithelial duodenal lymphocytes were excluded - as they may represent a separate type of psoriasis - another type of correlation between the skin and t he duodenal mucosa was found, namely a highly significant inverse corr elation between the number of CD3+ lymphocytes in non-involved skin an d the number of duodenal mast cells, which is highly elevated in psori asis, The results might indicate an interplay between skin and intesti nal mast cells and lymphocytes in a hitherto unknown way.