ACTIVATION OF CD8 T-CELLS WITH SPECIFICITY FOR MYCOBACTERIAL HEAT-SHOCK-PROTEIN-60 IN MYCOBACTERIUM-BOVIS BACILLUS CALMETTE-GUERIN-VACCINATED MICE

Authors
ZUGEL U KAUFMANN SHE
Citation
U. Zugel et She. Kaufmann, ACTIVATION OF CD8 T-CELLS WITH SPECIFICITY FOR MYCOBACTERIAL HEAT-SHOCK-PROTEIN-60 IN MYCOBACTERIUM-BOVIS BACILLUS CALMETTE-GUERIN-VACCINATED MICE, Infection and immunity, 65(9), 1997, pp. 3947-3950
Citations number
22
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
65
Issue
9
Year of publication
1997
Pages
3947 - 3950
Database
ISI
SICI code
0019-9567(1997)65:9<3947:AOCTWS>2.0.ZU;2-G
Abstract
Heat shock protein 60 (hsp60)-specific CD8 T cells lysed Mycobacterium Bovis BCG-infected macrophages in vitro and adoptively transferred pr otection against mycobacterial infection. Moreover, CD8 T cells with t his hsp60 specificity were activated in vivo by BCG vaccination, Our s tudies suggest there is participation of hsp60-specific CD8 T cells in BCG-induced immunity.