DNA-PROTEIN CROSS-LINKS IN LEUKOCYTES OF MICE INDUCED BY ZN, CD, AND PB

Authors
OSIPOV AN SYPIN VD KOLOMIJTSEVA GY POLSKY OG ILYINOV AN
Citation
An. Osipov et al., DNA-PROTEIN CROSS-LINKS IN LEUKOCYTES OF MICE INDUCED BY ZN, CD, AND PB, Biochemistry, 62(6), 1997, pp. 681-683
Citations number
10
Categorie Soggetti
Biology
Journal title
Biochemistry → ACNP
ISSN journal
00062979
Volume
62
Issue
6
Year of publication
1997
Pages
681 - 683
Database
ISI
SICI code
0006-2979(1997)62:6<681:DCILOM>2.0.ZU;2-0
Abstract
A single subdermal injection of CdCl2 or Pb(CH3COO)(2) results, togeth er with remarkable changes in the blood cell pattern, in increased DNA -protein cross-links in mouse leukocytes in 24 h; after 15 days the DN A-protein cross-linking returned to the initial level. In contrast, af ter injection of ZnSO4 a high level of DNA-protein cross-links is reta ined during the whole observation period (15 days). In the studied ran ge of doses the formation of DNA-protein cross-links is proportional t o the logarithm of the dose.