Mucoepidermoid carcinomas are malignant neoplasms that rarely involve
the skin. Composed of both mucus-secreting cells and epidermoid-type c
ells in various proportions, mucoepidermoid carcinomas occur most comm
only in salivary glands. In this case report, we describe a high-grade
mucoepidermoid carcinoma with cutaneous involvement. Although this pa
tient was referred for Mohs' micrographic surgery, further evaluation
showed either direct or metastatic extension from the parotid gland to
skin and distant metastases to the lung and bone. Despite extensive b
one involvement, serum levels of ionized calcium, phosphorus, and lact
ate dehydrogenase remained normal. In view of the widespread metastase
s, the treatment plan was altered to radiotherapy and chemotherapy ins
tead of surgery. Instructive lessons from this case include the recogn
ition by dermatologists of this rare entity, the importance of a detai
led history and complete evaluation of the patient before determining
appropriate therapy, and the necessity of individualizing diagnostic t
ests to a particular patient.