Neoplastic transformation of lichen planus is a rare event. However, s
quamous cell carcinoma may develop in 0.3%-3% of patients with the ora
l form of the disease. On the other hand, less than 30 cases arising i
n cutaneous lichen planus have been reported, and only four cases of v
errucous carcinoma in association with either form, one with an oral l
esion and three with cutaneous lesions (one hypertrophic and one ulcer
ative). This report describes the unusual progression of a hypertrophi
c lichen planus plaque of the right leg to a verrucous carcinoma in a
40-year-old woman.