FLUCONAZOLE TREATMENT OF NEONATES AND INFANTS WITH SEVERE FUNGAL-INFECTIONS

Citation
An. Gurpinar et al., FLUCONAZOLE TREATMENT OF NEONATES AND INFANTS WITH SEVERE FUNGAL-INFECTIONS, Journal of international medical research, 25(4), 1997, pp. 214-218
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy","Medicine, Research & Experimental
ISSN journal
03000605
Volume
25
Issue
4
Year of publication
1997
Pages
214 - 218
Database
ISI
SICI code
0300-0605(1997)25:4<214:FTONAI>2.0.ZU;2-0
Abstract
A total of 24 neonates and infants, aged from 2 days to 10 months, rec eived treatment with intravenous fluconazole for microbiologically doc umented or presumed fungal infection. The mean fluconazole dosage was 6 mg/kg/day (range 2 -16 mg/kg/day) and the mean duration of therapy w as 25 days (range 5 - 72 days). Efficacy was evaluated in neonates wit h proven fungal infections, as documented by the presence of pathogen at baseline. A positive clinical response was achieved in 23 of the 24 clinically evaluable patients (96%); eradication of the fungal organi sm was also achieved in 23 of the 24 evaluable patients (96%). Adverse events occurred in two patients (8%) but therapy was not discontinued in either patient. The present results confirm the efficacy and safet y of fluconazole in the treatment of neonates and infants with severe fungal infections.