A GENERAL ENTRY TO 10-HALOCOLCHICIDES AND 9-HALOISOCOLCHICIDES

Authors
CAVAZZA M PIETRA F
Citation
M. Cavazza et F. Pietra, A GENERAL ENTRY TO 10-HALOCOLCHICIDES AND 9-HALOISOCOLCHICIDES, Synthetic communications, 27(19), 1997, pp. 3405-3413
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
27
Issue
19
Year of publication
1997
Pages
3405 - 3413
Database
ISI
SICI code
0039-7911(1997)27:19<3405:AGET1A>2.0.ZU;2-P
Abstract
Readily accessible 10-tosyloxycolchicide (1) and LiX (X=Cl or Br or I) in MeOH/BF3.Et2O at reflux give 10-chloro- (2), 10-bromo- (4), or 10- iodocolchicide (5), in good yields. 9-Chloro- (7) and 9-bromoisocolchi dide (8) can be similarly obtained front 9-tosyloxyisocolchidide (6) a nd the method applies also to troponoids.