Y. Yazdanpanah et al., ORGANOMETRIC INVESTIGATIONS OF THE SPLEEN AND LIVER BY ULTRASOUND IN SCHISTOSOMA-MANSONI ENDEMIC AND NONENDEMIC VILLAGES IN SENEGAL, The American journal of tropical medicine and hygiene, 57(2), 1997, pp. 245-249
Citations number
15
Categorie Soggetti
Public, Environmental & Occupation Heath","Tropical Medicine
With the intention of ultrasonographically assessing hepatosplenic mor
bidity in Schistosoma mansoni infection and of validating the grading
system applied (Cairo classification), 191 subjects in a schistosomias
is endemic village and 247 controls from a nonendemic village in north
ern Senegal underwent sonographic examination of the liver and spleen.
Measurements of the diameters of the peripheral periportal vein branc
hes, the main portal vein stem, liver size (left lobe and right lobe),
and spleen length in the endemic village were compared with those in
the nonendemic village to evaluate the much discussed influence of S.
mansoni infection on those variables. To subtract this presumed influe
nce from reference values for the named variables, they are given as m
easured in the nonendemic village, stratified by body weight, enabling
future investigators on schistosomiasis-induced morbidity to refer to
these reference values. The 95th percentile regarding peripheral peri
portal vein branch diameter in the control groups was exceeded in 24%
of the subjects in the endemic group. It was exceeded by 6% for the ma
in portal vein stem diameter, 13% for the left Liver lobe, 12% for the
right liver lobe, and 14% for the spleen length. According to the Cai
ro classification, 97% of the endemic population and 81% of the contro
ls had periportal thickening of the Liver, mostly grade I. We conclude
that 1) hepatic morbidity in the S. mansoni endemic area was low, des
pite strikingly high intensities of infection; 2) the Cairo classifica
tion in its present form overestimates periportal thickening, especial
ly in the case of mild morbidity; and 3) body height-dependent referen
ce values, obtained from endemic controls, must be applied for organom
etric parameters.