The issue of modeling and control of multivariable chemical process sy
stems using the dynamic version of a popular multivariate statistical
technique, namely projection to latent structures (partial least squar
es or PLS) is addressed. Discrete input-output data are utilized to co
nstruct a projection-based dynamic model that captures the dominant fe
atures of the process under study. The structure of the resulting mode
l enables the synthesis of a multiloop control system. In addition, th
e design of feedforward control for multivariable systems using the dy
namic PLS framework is also presented. Three case studies are used to
illustrate the modeling and control of multivariable linear and nonlin
ear systems using the suggested approach.