PRELIMINARY-REPORT - TROGLITAZONE (CS-045) AMELIORATES ALBUMINURIA INSTREPTOZOTOCIN-INDUCED DIABETIC RATS

We studied the effect of troglitazone, a new oral antidiabetic agent t hat potentiates insulin action and reduces insulin resistance, on albu minuria in streptozotocin (STZ)-treated diabetic rats. Without affecti ng blood glucose level, blood pressure, and creatinine clearance, trog litazone treatment of diabetic rats significantly decreased the diabet es-associated albuminuria at all time points studied (4 to 12 weeks of treatment: diabetic 510 +/- 161 mu g/24 h v diabetic treated 112 +/- 34 mu g/24 h at 12 weeks, P<.05), These data suggest that troglitazone has potential in the treatment of diabetic nephropathy. Copyright (C) 1997 by W.B. Saunders Company.