EFFICIENT ISOLATION OF SUBACUTE SCLEROSING PANENCEPHALITIS VIRUS FROMPATIENT BRAINS BY REFERENCE TO MAGNETIC-RESONANCE AND COMPUTED TOMOGRAPHIC-IMAGES

Subacute sclerosing panencephalitis virus has been isolated with diffi culty from brains of infected patients. More strains are needed for th e study of the pathogenesis of this virus. To make the isolation more efficient, we selected portions to be examined from the brains of thre e patients with reference to findings of repeated magnetic resonance a nd computed tomographic imaging. Three cell lines susceptible to measl es virus field strains were used. In all three cases viruses were isol ated most effectively from recent lesions and with Vero cells. Our res ults suggested that these imaging methods and Vero cells could be used for improvement in the efficiency of isolation of this virus from pat ient brains.