PERIODIC ULTRAFILTRATION BY SINGLE-PASS FLOW USING HOLLOW-FIBER MEMBRANE MODULE

Periodic ultrafiltration of bovine serum albumin (BSA) solutions by si ngle-pass flow was conducted using a hollow fiber membrane module. In this method the filter cake formed on the membrane surface during filt ration was disrupted by periodically interrupting filtration. Thus, a much higher filtration rate, which led to an increased concentration r atio of protein solutions, was provided by periodic operation compared with what was produced by continuous operation. Influences of filtrat ion times (theta(f)) and sweeping times (theta(d)) on the filtration p erformance were examined.