DESIGN AND SYNTHESIS OF A TARGETED SET OF AROMATIC AMINO-ACID DERIVATIVES FOR IDENTIFICATION OF NEW LEAD COMPOUNDS

Authors
HORWELL DC KNEEN CO PRITCHARD MC RATCLIFFE GS ROBERTS E SUMANCHAUHAN N STEINER K BETCHE HJ
Citation
Dc. Horwell et al., DESIGN AND SYNTHESIS OF A TARGETED SET OF AROMATIC AMINO-ACID DERIVATIVES FOR IDENTIFICATION OF NEW LEAD COMPOUNDS, Bioorganic & medicinal chemistry letters, 7(15), 1997, pp. 1957-1962
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
15
Year of publication
1997
Pages
1957 - 1962
Database
ISI
SICI code
0960-894X(1997)7:15<1957:DASOAT>2.0.ZU;2-1
Abstract
A targeted set of 256 aromatic alpha-amino acid derivatives is describ ed to provide new lead compounds for biological screening. The utility is exemplified by identification of ligands for the human neuromedin B (hNMB) receptor, such as compound 3 (Ki hNMB 37 nM). (C) 1997 Elsevi er Science Ltd.