BENZOYLPHENOXY ANALOGS OF ISOPRENOID DIPHOSPHATES AS PHOTOACTIVATABLESUBSTRATES FOR BACTERIAL PRENYLTRANSFERASES

Authors
MARECAK DM HORIUCHI Y ARAI H SHIMONAGA M MAKI Y KOYAMA T OGURA K PRESTWICH GD
Citation
Dm. Marecak et al., BENZOYLPHENOXY ANALOGS OF ISOPRENOID DIPHOSPHATES AS PHOTOACTIVATABLESUBSTRATES FOR BACTERIAL PRENYLTRANSFERASES, Bioorganic & medicinal chemistry letters, 7(15), 1997, pp. 1973-1978
Citations number
35
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
15
Year of publication
1997
Pages
1973 - 1978
Database
ISI
SICI code
0960-894X(1997)7:15<1973:BAOIDA>2.0.ZU;2-3
Abstract
Photoactivatable benzophenone-containing analogs of isoprenyl diphosph ates have been synthesized and evaluated as substrates and inhibitors of three bacterial prenyltransferases: farnesyl diphosphate synthase ( FPS), hexaprenyl diphosphate synthase (HexPS)and undecaprenyl diphosph ate synthase (UPS). These analogs undergo chain extension and will all ow identification of hydrophobic active site residues of these enzymes . (C) 1997 Elsevier Science Ltd.