Dm. Marecak et al., BENZOYLPHENOXY ANALOGS OF ISOPRENOID DIPHOSPHATES AS PHOTOACTIVATABLESUBSTRATES FOR BACTERIAL PRENYLTRANSFERASES, Bioorganic & medicinal chemistry letters, 7(15), 1997, pp. 1973-1978
Photoactivatable benzophenone-containing analogs of isoprenyl diphosph
ates have been synthesized and evaluated as substrates and inhibitors
of three bacterial prenyltransferases: farnesyl diphosphate synthase (
FPS), hexaprenyl diphosphate synthase (HexPS)and undecaprenyl diphosph
ate synthase (UPS). These analogs undergo chain extension and will all
ow identification of hydrophobic active site residues of these enzymes
. (C) 1997 Elsevier Science Ltd.