NOVEL 7-HYDROXYCOUMARIN BASED FLUORESCENT LABELS

Authors
ADAMCZYK M CORNWELL M HUFF J REGE S RAO TVS
Citation
M. Adamczyk et al., NOVEL 7-HYDROXYCOUMARIN BASED FLUORESCENT LABELS, Bioorganic & medicinal chemistry letters, 7(15), 1997, pp. 1985-1988
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
15
Year of publication
1997
Pages
1985 - 1988
Database
ISI
SICI code
0960-894X(1997)7:15<1985:N7BFL>2.0.ZU;2-W
Abstract
Five new 7-hydroxy-8-(N-alkylaminomethyl)coumarin labels (6a-e) were p repared from 4-(4-carboxybutyl)-7-hydroxycoumarin (4) in 28-48% yield. Compared to 4-methylumbelliferone (4-MU, 1), the new fluorescent labe ls exhibited higher emission intensity over a broader pH range. Extinc tion coefficients, quantum yields and pKa values are also reported for these labels. (C) 1997 Elsevier Science Ltd.