SYNTHESIS OF CONFORMATIONALLY CONSTRAINED ANALOGS OF BRL-32872 - DETERMINATION OF STEREOCHEMISTRY AND RELATED PHARMACOLOGICAL PROPERTIES

Authors
SOUCHET M FOREST MC GERHARD U SMITH RJ CHEVAL B ROUANET S FAIVRE JF BRIL A
Citation
M. Souchet et al., SYNTHESIS OF CONFORMATIONALLY CONSTRAINED ANALOGS OF BRL-32872 - DETERMINATION OF STEREOCHEMISTRY AND RELATED PHARMACOLOGICAL PROPERTIES, Bioorganic & medicinal chemistry letters, 7(15), 1997, pp. 1989-1994
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
15
Year of publication
1997
Pages
1989 - 1994
Database
ISI
SICI code
0960-894X(1997)7:15<1989:SOCCAO>2.0.ZU;2-0
Abstract
2-Azabicyclo[2.2.2]octane derivatives have been used as conformational ly constrained structure of BRL-32872, in order to investigate the eff ect of molecular flexibility towards class III and class IV antiarrhyt hmic properties. Extensive NMR studies allowed the determination of th e configuration at C5. Stereoisomerism induces variability of biologic al profile. (C) 1997 Elsevier Science Ltd.