TRYPANOCIDAL ACTIVITY AND REDOX POTENTIAL OF HETEROCYCLIC-NAPHTHOQUINONES AND 2-HYDROXY-NAPHTHOQUINONES

Authors
GOULART MOF ZANI CL TONHOLO J FREITAS LR DEABREU FC OLIVEIRA AB RASLAN DS STARLING S CHIARI E
Citation
Mof. Goulart et al., TRYPANOCIDAL ACTIVITY AND REDOX POTENTIAL OF HETEROCYCLIC-NAPHTHOQUINONES AND 2-HYDROXY-NAPHTHOQUINONES, Bioorganic & medicinal chemistry letters, 7(15), 1997, pp. 2043-2048
Citations number
38
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
15
Year of publication
1997
Pages
2043 - 2048
Database
ISI
SICI code
0960-894X(1997)7:15<2043:TAARPO>2.0.ZU;2-7
Abstract
With the aim of understanding the influence of redox potentials on the trypanocidal activity, a series of quinones were tested in vitro with trypomastigotes of Trypanosoma cruzi and their first cathodic potenti als (Ep(cl)) measured by cyclic voltammetry. All quinones with Ep(cl) > -0.72V were active, while most of those with Ep(cl) < -0.72V were in active, suggesting a contribution of the easiness of reduction on the biological activity. (C) 1997 Elsevier Science Ltd.