OLIGODEOXYRIBONUCLEOTIDE PHOSPHOROTHIOATES KILL PROCYCLIC TRYPANOSOMA-BRUCEI-BRUCEI - QUANTITATIVE-DETERMINATION OF THEIR LD50

Authors
BOUZIN C BROUCKAERT S COTTEM D BERENS C SONVEAUX E
Citation
C. Bouzin et al., OLIGODEOXYRIBONUCLEOTIDE PHOSPHOROTHIOATES KILL PROCYCLIC TRYPANOSOMA-BRUCEI-BRUCEI - QUANTITATIVE-DETERMINATION OF THEIR LD50, Bioorganic & medicinal chemistry letters, 7(15), 1997, pp. 2071-2076
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
15
Year of publication
1997
Pages
2071 - 2076
Database
ISI
SICI code
0960-894X(1997)7:15<2071:OPKPT>2.0.ZU;2-Q
Abstract
Phosphorothioates kill the procyclic form of T. brucei brucei by a non antisense but sequence dependent effect. The alamar Blue(TM) method a llowed an easy microscale determination of their antiparasitic effect. The LD50 of the sequences tested was in the range of 11-20 mu M. (C) 1997 Elsevier Science Ltd.