ALTERATION OF SUBJECTIVE AND OBJECTIVE PA RAMETERS BY DANAZOL-THERAPYIN PATIENTS WITH ENDOMETRIOSIS-ASSOCIATED INFERTILITY

41 patients with an endometriosis-associated infertility were incorpor ated in a prospective study and treated with danazol 600 mg daily for 6 months. Before and after chemotherapy, a laparoscopy was performed ( rAFSc). Subjective symptoms, adverse effects, laboratory changes and p regnancy rate were documented for a period of one year. A significant reduction of the endometriotic implants was demonstrated in 94% of the patients. The mean rAFS-score decreased from 17.0 to 6.5 after therap y. The subjective symptoms also changed positively: after danazol the dysmenorrhoea disappeared in 77%, the dyspareunia in 94% and the pelvi c pains in 74%. Laboratory parameters showed an increase of the SGOT i n 33%, of the SGPT in 46%. Although side effects were obvious, 84% of the women quoted danazol as ''well tolerable'' medication. The pregnan cy rate during the first year reached 38%.