PLACENTAL-TRANSFER OF CEFPIROME (HR-810) - A STUDY OF FETAL CONCENTRATIONS AFTER IN-VITRO INFUSION OF HUMAN PLACENTA AT TERM

Cefpirome (CPO) is a new parenteral cephalosporin with a wide antibact erial spectrum. In order to explore the possibility of using CPO in la te pregnancy, we studied its placental transfer in vitro in a model of human placenta infusion. Mother-to-foetus in vitro transfer of CPO is high, similar to that of amoxicillin, with a placental clearance inde x of 0.20. A pharmacokinetic simulation based upon this result and dat a from litterature suggests that CPO concentrations in foetal blood an d amniotic fluid should be appropriate for the treatment of severe mat erno-foetal infections in late pregancy. These preliminary results nee d to be confirmed by in vivo pharmacokinetic and clinical studies befo re recommending the use of CPO in late pregnancy.