BORRELIDIN IS AN ANGIOGENESIS INHIBITOR - DISRUPTION OF ANGIOGENIC CAPILLARY VESSELS IN A RAT AORTA MATRIX CULTURE MODEL

Authors
WAKABAYASHI T KAGEYAMA R NARUSE N TSUKAHARA N FUNAHASHI Y KITOH K WATANABE Y
Citation
T. Wakabayashi et al., BORRELIDIN IS AN ANGIOGENESIS INHIBITOR - DISRUPTION OF ANGIOGENIC CAPILLARY VESSELS IN A RAT AORTA MATRIX CULTURE MODEL, Journal of antibiotics, 50(8), 1997, pp. 671-676
Citations number
24
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
50
Issue
8
Year of publication
1997
Pages
671 - 676
Database
ISI
SICI code
0021-8820(1997)50:8<671:BIAAI->2.0.ZU;2-F
Abstract
Borrelidin, an antibiotic from Streptomyces rochei, was found to be an angiogenesis inhibitor in a rat aorta matrix culture model which form s capillary vessels in vitro. Borrelidin strongly inhibited capillary tube formation with a 50%-inhibitory concentration value of 0.8 nM, an d decreased the number of capillary tubes within 24 hours when added a fter maturation of tube formation. Borrelidin remarkably disrupted cap illary tubes in a dose-dependent manner, by inducing apoptosis of the tube-forming cells.