A SYNTHETIC APPROACH TO BENANOMICIN-A .1. SYNTHESIS OF 5,6-DIHYDROBENZO[A]NAPHTHACENEQUINONE

Authors
HIROSAWA S NISHIZUKA T KONDO S IKEDA D TAKEUCHI T
Citation
S. Hirosawa et al., A SYNTHETIC APPROACH TO BENANOMICIN-A .1. SYNTHESIS OF 5,6-DIHYDROBENZO[A]NAPHTHACENEQUINONE, Journal of antibiotics, 50(8), 1997, pp. 685-689
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
50
Issue
8
Year of publication
1997
Pages
685 - 689
Database
ISI
SICI code
0021-8820(1997)50:8<685:ASATB.>2.0.ZU;2-3
Abstract
5,6-Dihydrobenzo[a]naphthacenequinone has been constructed by DIELS-AL DER reaction of an outer-ring diene with a naphthoquinone regioselecti vely. Similarly, the 14-hydroxy-5,6-dihydrobenzo[a]naphthacenequinone (13) has also been synthesized via the reaction of vinylketene acetal (11) with naphthoquinone.