DIRECTED SYNTHESIS OF ISOMERIC THIAZOLE AND IMIDAZOLE DERIVATIVES FROM METHYL ISOTHIOCYANATE

Authors
NEDOLYA NA BRANDSMA L TROFIMOV BA
Citation
Na. Nedolya et al., DIRECTED SYNTHESIS OF ISOMERIC THIAZOLE AND IMIDAZOLE DERIVATIVES FROM METHYL ISOTHIOCYANATE, Tetrahedron letters, 38(35), 1997, pp. 6279-6280
Citations number
2
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
35
Year of publication
1997
Pages
6279 - 6280
Database
ISI
SICI code
0040-4039(1997)38:35<6279:DSOITA>2.0.ZU;2-M
Abstract
Reaction of methyl isothiocyanate with two equivalents of lithium diis opropylamide, followed by alkylation with dimethyl sulfate gives 2-met hyl-5-N, N-dimethylaminothiazole in a high yield. The isomer, 1-methyl -2,5-bis(methylthio)imidazole is obtained in a high yield, if prior to methylation, the reaction mixture is stirred for some period with wat er at room temperature. (C) 1997 Elsevier Science Ltd.