INTERACTION OF AMIODARONE AND DESETHYLAMIODARONE WITH DIMYRISTOYL PHOSPHATIDYLCHOLINE BILAYERS

The interaction between amiodarone or desethylamiodarone and dimyristo yl phosphatidylcholine bilayers was investigated by two optical techni ques, quasi-elastic light scattering (QLS) and Fourier transform infra red spectroscopy (FT-IR), The results show that in the presence of the drugs, the bilayer phase transition point is lowered and at high drug concentration there is an incresase in the vesicle size, The FT-IR re sults indicate interactions in the hydrocarbon region and also in the carbonyl interface region of the bilayers. There may be an interdigita tion of two leaflets of the bilayer, We discussed these results compar atively with those obtained from propranolol whose effect was analogou s and previously studied.