5-FLUOROURACIL DERIVATIVES .22. SYNTHESIS AND ANTITUMOR ACTIVITIES OF1-CARBAMOYL-5-FLUOROURACILS

Authors
OZAKI S KONG XZ WATANABE Y HOSHIKO T KOGA T OGASAWARA T TAKIZAWA T FUJISAWA H IIGO M HOSHI A
Citation
S. Ozaki et al., 5-FLUOROURACIL DERIVATIVES .22. SYNTHESIS AND ANTITUMOR ACTIVITIES OF1-CARBAMOYL-5-FLUOROURACILS, Chemical and Pharmaceutical Bulletin, 45(8), 1997, pp. 1372-1375
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
45
Issue
8
Year of publication
1997
Pages
1372 - 1375
Database
ISI
SICI code
0009-2363(1997)45:8<1372:5D.SAA>2.0.ZU;2-2
Abstract
Fifty-four 1-carbamoyl-5-fluorouracils were synthesized from 5-fluorou racil and isocyauate or amine. Antitumor activity was tested in the L- 1210 tumor system, and 11 compounds gave better values of therapeutic ratio than HCFU (1-hexylcarbamoyl-5-fluorouracil), 1-(4-Methoxycyclohe xylcarbamoyl)-5-fluorouracil gave the best result.