C. Roll et al., HETEROTOPIC AUXILIARY LIVER-TRANSPLANTATION IN A 3-YEAR-OLD BOY WITH ACUTE LIVER-FAILURE AND APLASTIC-ANEMIA, Transplantation, 64(4), 1997, pp. 658-660
Background. Auxiliary liver transplantation offers an alternative meth
od to conventional transplantation in acute liver failure. It is espec
ially challenging for children because lifelong immunosuppression may
be avoided. However, experience with this procedure is rare and there
is controversy about whether to place the graft orthotopically or hete
rotopically. Methods. We present the case of a 3-year-old boy with acu
te liver failure due to non-ABC hepatitis complicated by aplastic anem
ia who underwent auxiliary liver transplantation. Segments 2 and 3 of
the graft were implanted heterotopically in the right lower abdomen. R
esults. Good liver function was immediately restored. Aplastic anemia
resolved 3 weeks after transplantation. Immunosuppressive therapy was
discontinued after 14 months, and the graft was left to atrophy. Thirt
y-nine months after transplantation the boy is alive and well with nor
mal liver function tests and normal blood cell counts. Conclusions. He
terotopic auxiliary liver transplantation allowed recovery of the nati
ve liver in a child with acute liver failure and aplastic anemia due t
o non-ABC hepatitis.