VON-WILLEBRANDS-DISEASE

Von Willebrand's disease is the most frequent form among hereditary he morrhagic diatheses characterized by autosomal-dominant and less frequ ent resessive heredity. The disease is caused by quantitative or quali tative defects of von Willebrand's plasmic factor which in hemostasis functions as a protein-carrier of coagulation factor VIII and particip ates in reactions of platelet interaction with damaged vascular wail a t the stages of adhesion, spreading and aggregation of platelets. Von Willebrand's disease presents with variable clinical and laboratory pa rameters reflecting different disorders of the von Willebrand's factor . This explains differential therapy of hemorrhagic syndrome.