HYPOXIA OF TISSUE PERIPHERAL SHUNTING UND ER HEMODILUTION AND OXYGEN BREATHING

A comprehensive analysis of the main parameters of circulation, gas ex change and blood gases has been made basing on dog and cat experiments with models of complete and partial replacement of blood for gas-carr ying substances (perfluoroorganic compounds) and plasma substitutes. H emodilution of different degree in oxygen breathing enabled detection and description of hypoxia of tissue peripheral shunting. It is charac terized by elevated patial oxygen pressure in mixed venous blood under arterial hyperoxia. This hypoxia aggravates posttransfusion oxygen in sufficiency in the recipient's tissues. Mixed posttransfusion hypoxia is more severe than anemic hypoxia arising in moderate blood loss repl acement with blood substitutes in breathing atmospheric air.