Kk. Anand et Jr. Zuniga, EFFECT OF AMILORIDE ON SUPRATHRESHOLD NACL, LICL, AND KCL SALT TASTE IN HUMANS, Physiology & behavior, 62(4), 1997, pp. 925-929
The purpose of this study was to investigate normal Variances in the r
esponse magnitudes of suprathreshold concentrations of NaCl, LiCl, and
KCI salts and amiloride on the anterior human tongue. Random equimola
r concentrations of salt solutions were delivered to spatially matched
flow chambers of 20 volunteers at 3 different sessions. A cross-modal
magnitude matching procedure was used to scale salt taste-intensity j
udgments. After each salt test, amiloride (100 mu m) was delivered for
5 min and the test was repeated. A least-square regression analysis o
f each subject's function between log molar concentration and log resp
onse demonstrated that every subject scaled the dynamic range of salts
. There were no differences in either the mean regression or intercept
among the 3 salts. Repeated-measures analysis demonstrated a statisti
cal effect of amiloride on the before/after difference in the regressi
on (p = 0.02) and intercept (p < 0.0001) of NaCl and LiCl functions. P
ostamiloride NaCl and LiCl coefficient of variance of response was inc
reased. Amiloride had no effect on the before/after difference in the
regression and intercept of KCl power functions or the variance of res
ponse. The results suggest that, after amiloride, NaCl and LiCl suprat
hreshold salt taste intensities are reduced, but there are individual
variabilities of reduced intensity that are never completely eliminate
d. (C) 1997 Elsevier Science Inc.