FROM RECEPTOR TO NUCLEUS - THE SMAD PATHWAY

Authors
BAKER JC HARLAND RM
Citation
Jc. Baker et Rm. Harland, FROM RECEPTOR TO NUCLEUS - THE SMAD PATHWAY, Current opinion in genetics & development, 7(4), 1997, pp. 467-473
Citations number
49
Categorie Soggetti
Biology,"Cell Biology","Biothechnology & Applied Migrobiology","Genetics & Heredity
Journal title
Current opinion in genetics & development → ACNP
ISSN journal
0959437X
Volume
7
Issue
4
Year of publication
1997
Pages
467 - 473
Database
ISI
SICI code
0959-437X(1997)7:4<467:FRTN-T>2.0.ZU;2-U
Abstract
The transforming growth factor-beta (TGF-beta) superfamily plays a cen tral role in the specification and patterning of cells in the early em bryo. Several years ago, the TGF-beta s were shown to signal through s erine/threonine receptor kinases. Now, with the identification of Smad proteins, we can trace the TGF-beta signal transduction pathway from the receptors into the nucleus.