NEW INSIGHTS INTO SEGMENTATION AND PATTERNING DURING VERTEBRATE SOMITOGENESIS

Understanding how muscles and the skeleton develop is essential to und erstanding how distinct form arises in different vertebrate organisms. The meristic somites give rise to the serially-repeated precursors of the axial skeleton and musculature. Recent studies of somitogenesis h ave shed light upon the mechanisms of segmentation in vertebrates and the relationship between segmentation and patterning. Significant adva nces have also been made in connecting signalling molecules that posse ss somite patterning activity with downstream effector genes.