CHARACTERIZATION OF AMYLOID-BETA PROTEIN SPECIES IN CEREBRAL AMYLOID ANGIOPATHY OF A SQUIRREL-MONKEY BY IMMUNOCYTOCHEMISTRY AND ENZYME-LINKED-IMMUNOSORBENT-ASSAY

Authors
SAWAMURA N TAMAOKA A SHOJI S KOO EH WALKER LC MORI H
Citation
N. Sawamura et al., CHARACTERIZATION OF AMYLOID-BETA PROTEIN SPECIES IN CEREBRAL AMYLOID ANGIOPATHY OF A SQUIRREL-MONKEY BY IMMUNOCYTOCHEMISTRY AND ENZYME-LINKED-IMMUNOSORBENT-ASSAY, Brain research, 764(1-2), 1997, pp. 225-229
Citations number
18
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
764
Issue
1-2
Year of publication
1997
Pages
225 - 229
Database
ISI
SICI code
0006-8993(1997)764:1-2<225:COAPSI>2.0.ZU;2-2
Abstract
We analyzed the composition of amyloid beta protein (A beta) species i n cerebral amyloid angiopathy (CAA) of an aged squirrel monkey. Immuno cytochemistry demonstrated that the cerebral cortex contained no lesio ns other than widespread CAA with A beta 40 as its apparent major comp onent. However, enzyme-linked immunosorbent assay revealed that A beta 42(43) predominated over A beta 40 in a formic acid-extracted cortica l fraction. These findings suggest possible underestimation of A beta 42(43) levels in some previous immunocytochemical investigations. (C) 1997 Elsevier Science B.V.