THE CRITICAL ROLE OF NUCLEUS-ACCUMBENS DOPAMINE SYSTEMS IN THE MEDIATION OF FIXED-INTERVAL SCHEDULE-CONTROLLED OPERANT-BEHAVIOR

Authors
CORYSLECHTA DA PAZMINO R BARE C
Citation
Da. Coryslechta et al., THE CRITICAL ROLE OF NUCLEUS-ACCUMBENS DOPAMINE SYSTEMS IN THE MEDIATION OF FIXED-INTERVAL SCHEDULE-CONTROLLED OPERANT-BEHAVIOR, Brain research, 764(1-2), 1997, pp. 253-256
Citations number
17
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
764
Issue
1-2
Year of publication
1997
Pages
253 - 256
Database
ISI
SICI code
0006-8993(1997)764:1-2<253:TCROND>2.0.ZU;2-K
Abstract
Microinjections of the irreversible dopamine antagonist EEDQ ( N-ethox ycarbonyl-2-ethoxy-1,2-dihydroquinoline), into nucleus accumbens but n ot into dorsal striatum, markedly decreased response rates on a fixed interval schedule of reinforcement. These preferential effects in nucl eus accumbens could be prevented by selectively activating either D-1 or D-2 receptors. These data demonstrate a critical role for mesolimbi c dopamine systems in the mediation of fixed interval schedule-control led operant behavior. (C) 1997 Elsevier Science B.V.