OPIOIDS POTENTIATE TRANSMITTER RELEASE FROM SK-N-SH HUMAN NEUROBLASTOMA-CELLS BY MODULATING N-TYPE CALCIUM CHANNELS

Authors
KEREN O GAFNI M SARNE Y
Citation
O. Keren et al., OPIOIDS POTENTIATE TRANSMITTER RELEASE FROM SK-N-SH HUMAN NEUROBLASTOMA-CELLS BY MODULATING N-TYPE CALCIUM CHANNELS, Brain research, 764(1-2), 1997, pp. 277-282
Citations number
54
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
764
Issue
1-2
Year of publication
1997
Pages
277 - 282
Database
ISI
SICI code
0006-8993(1997)764:1-2<277:OPTRFS>2.0.ZU;2-2
Abstract
Opioids induce dual (inhibitory and excitatory) regulation of depolari zation-evoked [H-3]dopamine release in SK-N-SH cells through either mu or delta receptors. The potentiation of dopamine release by opioid ag onists is mediated by N-type voltage-dependent calcium channels and do es not involve G(i)/G(o) proteins. Removal of the excitatory opioid ef fect by blockade with omega-conotoxin, an N-channel antagonist, reveal s the inhibitiory effect of opioids on release, thus suggesting that b oth modulatory effects of opioids are exerted in parallel. (C) 1997 El sevier Science B.V.