ENANTIOMERIC AND DIASTEREOMERIC ESTERS OF 2-METHOXYMETHYL-PYRROLIDINE-1-DITHIOCARBOXYLIC ACIDS

Authors
DOLLING W HOCKE I VERJUS P BIEDERMANN M HARTUNG H
Citation
W. Dolling et al., ENANTIOMERIC AND DIASTEREOMERIC ESTERS OF 2-METHOXYMETHYL-PYRROLIDINE-1-DITHIOCARBOXYLIC ACIDS, Monatshefte fuer Chemie, 128(8-9), 1997, pp. 881-891
Citations number
30
Categorie Soggetti
Chemistry
Journal title
Monatshefte fuer Chemie → ACNP
ISSN journal
00269247
Volume
128
Issue
8-9
Year of publication
1997
Pages
881 - 891
Database
ISI
SICI code
0026-9247(1997)128:8-9<881:EADEO2>2.0.ZU;2-0
Abstract
Formation of the 2-methoxymethyl-pyrrolidine-1-dithiocarboxylates 2-4 and alkylation of 2 and 3 were studied. Enantiomeric and diastereomeri c derivatives of 4, the preparation of diastereomeric mixtures of 4 by alkylation of 3 in the presence of strong bases, and formation of 6 b y phase transfer alkylation of 2 are described. The two enantiomers of 2-(4-bromophenyl)-2-oxo-ethyl 2-methoxymethylpyrrolidine-1-dithiocarb oxylate 2 have been characterized by X-ray analysis.