SYNTHESIS OF IODINATED AND RADIOIODINATED -2-BETA-CARBOMETHOXY-3-BETA-(3',4'-DICHLOROPHENYL) NORTROPANE (BETA-CDIT) - A LIGAND FOR THE DOPAMINE TRANSPORTER

Authors
EMOND P BOAZI M DUCHENE A CHALON S BESNARD JC GUILLOTEAU D FRANGIN Y
Citation
P. Emond et al., SYNTHESIS OF IODINATED AND RADIOIODINATED -2-BETA-CARBOMETHOXY-3-BETA-(3',4'-DICHLOROPHENYL) NORTROPANE (BETA-CDIT) - A LIGAND FOR THE DOPAMINE TRANSPORTER, Journal of labelled compounds & radiopharmaceuticals, 39(9), 1997, pp. 757-772
Citations number
18
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
39
Issue
9
Year of publication
1997
Pages
757 - 772
Database
ISI
SICI code
0362-4803(1997)39:9<757:SOIAR->2.0.ZU;2-V
Abstract
The synthesis of (E)-N-(3-iodoprop-2-enyl)-2 beta-carbomethoxy-3 beta- (3', 4'-dichiorophenyl) nortropane (beta-CDIT) and its radioiodinated analogues is described. Three different synthetic methods are reported for the preparation of (E)-N-[3-(tributylstannyl)-2-enyl]-2 beta carb omethoxy-3 beta-(3', 4'-dichlorophenyl) nortropane, which was iododest annylated for the preparation of the corresponding iodinated derivativ e. We also report the radiolabelling of beta-CDIT with I-125 Or I-123 that could be used for in vitro and in vivo exploration of the dopamin e transporter.