HYDROTROPIC SOLUBILIZATION OF FLURBIPROFEN

The solubilization of flurbiprofen (1), a drug practically insoluble i n water, using various physiologically active hydrotropic agents has b een investigated, In order to gain insight into the probable mechanism of solubilization solubility, spectral, typical properties of hydrotr opes, solution properties, gel formation, and paste formation were stu died with structural variation in the hydrotropes. The results indicat e that the enhanced solubility of 1 in the presence of hydrotropes at lower hydrotrope concentrations is due to a weak ionic interaction and at higher concentration, the formation of molecular aggregates seems to be a possible mechanism for hydrotropic solubilization.