ALLOGENEIC TRANSPLANTATION AFTER A CONDITIONING REGIMEN WITH IFOSFAMIDE, CARBOPLATIN AND ETOPOSIDE (ICE)

Successful allogeneic hematopoietic transplants require conditioning r egimens with sufficient immunosuppression to allow acceptance of the a llograft, Cyclophosphamide, in combination either with TBI or with che motherapeutic drugs, is the keystone of commonly used regimens, The to xicities of TBI and tumor resistance to cyclophosphamide create a nich e for alternative, chemotherapy-based conditioning regimens, We report successful allogeneic stem cell transplantation after an ifosfamide-b ased regimen with ifosfamide 20 g/m(2), carboplatin 1.8 g/m(2) and eto poside 3 g/m(2) (ICE) in divided doses over 6 days, Engraftment was pr ompt with neutrophils greater than or equal to 20 x 10(9)/l on day +10 and platelets >20 x 10(9)/l on day +18. Engraftment of donor cells wa s documented by chromosome analysis and by VNTR analysis, An ifosfamid e-based regimen provides sufficient immunosuppression for hematopoieti c allograft acceptance in the absence of cyclophosphamide or of TBI.