Purpose: To illustrate the spectrum of sarcoidosis involving the eye a
nd brain and the difficulties of confirming its clinical diagnosis Met
hods: The presentation of two unusual case reports of patients with oc
ular and cerebral involvement with sarcoidosis. Results: Tissue biopsy
, an essential component in the differential diagnosis, was required t
o confirm the diagnosis of sarcoidosis in each patient. Conclusions: S
arcoidosis remains an enigmatic disease with protean manifestations an
d widely differing outcomes.