2 CASES OF HYPERGRANULAR ACUTE LYMPHOBLASTIC-LEUKEMIA

Authors
BOLADOMARTINEZ E VIVANCOJIMENEZ M GARCIARAMIREZ F RUIZREYES G RUIZARGUELLES A RUIZARGUELLES GJ
Citation
E. Boladomartinez et al., 2 CASES OF HYPERGRANULAR ACUTE LYMPHOBLASTIC-LEUKEMIA, Revista de Investigacion Clinica, 49(3), 1997, pp. 227-230
Citations number
25
Categorie Soggetti
Medicine, General & Internal
Journal title
Revista de Investigacion Clinica → ACNP
ISSN journal
00348376
Volume
49
Issue
3
Year of publication
1997
Pages
227 - 230
Database
ISI
SICI code
0034-8376(1997)49:3<227:2COHAL>2.0.ZU;2-9
Abstract
Two patients with hypergranular acute lymphoblastic leukemia are prese nted: they represent 1.4% of patients with acute lymphoblastic leukemi a studied and treated in a single institution in the past 12 years. Th is frequency is substantially lower than that reported in Caucasian po pulations. The blast cells of the patients disclosed an early-B phenot ype, displaying CD45, CD10 and CD19 antigens. The cytoplasmic granules were positive for the PAS reaction. Both patients died early after st arting treatment; a poor prognosis has been recorded previously for pa tients with this type of malignancy.