S. Yokota et al., PRETREATMENT WITH TOPICAL 60-PERCENT LIDOCAINE TAPE REDUCES PAIN ON INJECTION OF PROPOFOL, Anesthesia and analgesia, 85(3), 1997, pp. 672-674
We determined whether pretreatment with topical 60% lidocaine tape red
uced the incidence of pain on injection of propofol compared with mixi
ng intravenous lidocaine with propofol. In a randomized, double-blind
trial, 90 patients were allocated to one of three groups: pretreatment
with a bioocclusive dressing and administration of a premixed solutio
n of propofol 180 mg and 2 mt of normal saline (Group A); pretreatment
with 60% lidocaine tape and a premixed solution of propofol and norma
l saline (Group B); or pretreatment with a bioocclusive dressing and a
premixed solution of propofol 180 mg and lidocaine 40 mg (Group C). T
he incidences of pain in Groups A, B, and C were 86.7%, 33.4%, and 20%
, respectively. Group B and Group C had a significantly lower incidenc
e of pain than Group A. There was no significant difference in the inc
idence of pain between Group B and Group C. There was no significant d
ifference in the distribution of site of pain on injection of propofol
among the three groups. Pretreatment with topical 60% lidocaine tape
reduced the incidence of pain on injection of propofol similar to that
of intravenous lidocaine mixed with propofol. Implications: Pretreatm
ent with topical 60% lidocaine tape reduces the pain associated with i
njection of propofol, a frequently used intravenous anesthetic. This a
pproach should increase patient comfort during induction of anesthesia
.